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Heterosynaptic eLTD takes place at synapses adjacent into the stimulated synapses. As an example, stimulation of Schaffer collaterals in hippocampal CA1 leads to a persistent decrease in GABAergic inhibition of CA1 pyramidal neurons (106). The mechanism of eLTD at hippocampal inhibitory synapses appears to have to have inhibition of adenylyl cyclas

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